When the role of COX-2 in primary effusion lymphoma (PEL) using nimesulide, a COX-2 specific nonsteroidal anti-inflammatory drug (NSAID) was examined, it was found to be efficacious in inducing proliferation arrest in EBV positive as well as KSHV positive cells (Paul et al., 2011). This evidence concerns the gene PTGS2 and primary effusion lymphoma.