IL1A and cryopyrin-associated periodic syndrome: In 2008, rilonacept (Hoffman et al., 2008), a soluble IL-1 decoy receptor, that neutralizes either IL-1α or IL-1β, received US Food and Drug Administration (FDA) approval in CAPS patients, and Canakinumab (Ilaris®) in 2009 (Chakraborty et al., 2012).