Kang X. et al. (2015) found that Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) deficiency exhausts mouse AML stem cells, but does not affect normal hematopoiesis. This discovery provides hope that there may likewise be similar pathways in PCSCs. The hypoxia-inducible factor (HIF) pathway may be one of such pathways in prostate cancer. HIF signaling is elevated in PCSC population and promotes stemness and self-renewal of PCSCs (Ma et al., 2011; Marhold et al., 2015). The gene discussed is LAIR1; the disease is prostate carcinoma.