SOCS3 and myeloid sarcoma: Here, we report that miR-384 over-expression leads to an imbalance in Th17/Treg ratios, resulting in exacerbation of EAE with severe demyelination, through the promotion of Th17 cell differentiation by targeting SOCS3. This miR-384-associated Th17/Treg imbalance represents a potential therapeutic target for MS and a novel indicator of disease risk (Yu et al., 2015).