HTT and Huntington disease: For targeting specific sequence of huntingtin mRNA, siRNAs, and ASOs were successfully tested in HD mouse models (Wang et al., 2005; DiFiglia et al., 2007; Boudreau et al., 2009; Carroll et al., 2011; Kordasiewicz et al., 2012; Ostergaard et al., 2013; Southwell et al., 2014).