LRRK2 and Parkinson disease: Most PD-specific mutations of LRRK2 occur in the afore-mentioned regions and lead to autosomal recessive and several sporadic PD, which hints at the importance of these enzymes in the pathogenesis (Funayama et al., 2005; Gilks et al., 2005; Kachergus et al., 2005; Tan et al., 2007; Martin et al., 2014).