Previously, it has been demonstrated that hypoxia could drive glioblastoma multiforme cells into a more aggressive and malignant state through Notch1-induced TRPC6 overexpression which in turn activated the calcineurin-nuclear factor of activated T-cell (NFAT) pathway and increased Ca2+ influx (Chigurapati et al., 2010). This evidence concerns the gene NOTCH1 and glioblastoma.