Although changes in metabolic parameters were not reported in these studies, numerous studies report that lower resting PTX3 concentrations are negatively associated with circulating concentrations of proinflammatory cytokines, triglycerides, insulin, glucose, and the HOMA-IR index of insulin resistance [11–13, 65–67, 75] and incrementally lower with increased parameters of metabolic syndrome [65, 67]. Here, PTX3 is linked to Insulin resistance.