Therefore, it is reasonable to speculate that therapeutic approaches (i.e., weight loss, regular physical exercise, and the potential development of pharmacological interventions) which elevate circulating PTX3 concentrations in obese individuals will help restore obesity-related inflammatory imbalances and shift the systemic and local inflammatory microenvironments to an anti-inflammatory milieu. This evidence concerns the gene PTX3 and obesity due to melanocortin 4 receptor deficiency.