PTX3 and obesity due to melanocortin 4 receptor deficiency: Furthermore, this review will address the therapeutic potential of PTX3 to improve obesity-related inflammatory imbalance, and because of the reported elevations in PTX3 following aerobic exercise [12, 13, 17], this review will address the possibility of utilizing aerobic exercise as a nonpharmacological anti-inflammatory treatment strategy to enhance plasma PTX3 concentrations in obese individuals.