Maternally expressed gene 3 (MEG3) is a myeloid-related lncRNA that has been shown to act as tumor suppressor in solid tumors.7, 8 Previous data have demonstrated that MEG3 is capable of increasing the protein level of the tumor suppressor p53 and enhancing p53 binding to its target promoters.9 In consequence, it is very evident that MEG3 can inhibit tumorigenesis through a p53-dependent manner. The gene discussed is TP53; the disease is neoplasm.