It is well-known that MEG3 protects the p53 from degradation, and thus inhibits tumor growth in a p53-dependent fashion.35 Our experiments extend our understanding of the molecular events leading to AML leukemogenesis, where decreased expression of MEG3 significantly restricts the increase of the tumor suppressor p53 protein.34, 35, 36 These observations often further support for a common tumor suppressive mechanism, whereby MEG3 functions as a tumor suppressor, at least partly via the activation of p53 in multiple cancers. The gene discussed is MEG3; the disease is acute myeloid leukemia.