For subsequent cell model experiments, we also investigated the genetic backgrounds (Supplementary Tables 1 and 2) and p53 levels (Supplementary Figure 1A) of eight representative cell lines derived from AML (K562, TF-1, MOLM-13, U937, NB4, Kasumi-1, KG-1 and HL-60) and the correlations between WT1, TET2 mutation status/expression levels and MEG3 inactivation in these cells (Supplementary Figure 1B). Here, WT1 is linked to acute myeloid leukemia.