Consistent with this, both etoposide and cisplatin increased NFκB luciferase reporter activity in LN229 cells (Fig. 4C) as well as in a cell line from a non-brain neural crest-derived cancer, childhood neuroblastoma (CHLA-255 cells, Supplementary Fig. S5), further supporting NFκB involvement in the response to chemotherapy. This evidence concerns the gene NFKB1 and cancer.