The detection of pyramidal lobe-like and lingual thyroid tissue in Wnt4- and Noggin-transgenic mice might suggest that similar congenital abnormalities in humans, sometimes presenting as combined thyroid dysgenesis or agenesis with ectopic thymus tissue67–69 arise due to aberrations in Wnt or BMP signaling pathways during development. The gene discussed is WNT4; the disease is thyroid gland disorder.