This model included WI-38, normal human fibroblasts, WI-38/hTERT/H-Ras/GSE, immortalized WI-38 that were transformed by a concomitant expression of H-Rasv12 and wild type p53 inactivating peptide (GSE56), and two tumor-derived lines (TL) that were generated by subcutaneous injection of the WI-38/hTERT/H-Ras/GSE into nude mice57. The gene discussed is TP53; the disease is neoplasm.