Overall, 5162 SNPs from 43 TCPTP pathway genes in the six GWAS datasets from the Transdisciplinary Research in Cancer of the Lung and The International Lung Cancer Consortium (TRICL-ILCCO) Consortium were identified, and their associations with lung cancer risk are shown in the Manhattan plot (Fig. 1A). The gene discussed is PTPN2; the disease is lung carcinoma.