SFRP5 and hydrops fetalis: DNA methylation of the promoter region of a specific gene should suppress that gene expression; however, it was apparent that the percentage of methylation in Sfrp5 promoter was not connected to Sfrp5 expression in ING fat depots in our model, for example, ING fat of 12‐week‐old‐mice eating HF had not only the highest Sfrp5 mRNA but also high Sfrp5 methylation (Fig. 6E and F).