In this experiment, Sfrp5 mRNA levels were fourfold elevated in ING fat of 12‐week‐old mice fed a HF compared to 10 day and 8‐week‐old mice fed STD diet (Fig. 6E), which is consistent with HF‐induced increase of body composition (Fig. 6A–D). The gene discussed is SFRP5; the disease is hydrops fetalis.