NOS2 and asthma: Benito Pescador et al. (2012) conducted a case–control study in Spain with 241 patients with CRSwNP (with and without asthma) and 245 controls to determine whether polymorphisms in genes implicated in inflammatory pathways (Leukotriene C4 Synthase [LTC4S], Cysteinyl Leukotriene Receptor 1 [CYSLTR1], Prostaglandin D2 Receptor [PTGDR], and Nitric Oxide Synthase [NOS2]) are associated with NP.