Interestingly, Beaumont et al. [42] demonstrated that the down-regulation of miR-122 was associated with the up-regulation of TGF-β1 expression, increasing the severity of myocardial fibrosis in patients with aortic stenosis, which is the most frequent valvular complication in BAV patients [43]. Here, TGFB1 is linked to Myocardial fibrosis.