The treatment for hypertension, DM or hyperlipidemia was respectively used as the independent variable with the adjustment of age and gender in linear regression analyses, and it was observed that RNase-L was associated with the treatment for hypertension treatment (β = −0.121, P = 0.020, Table 3, Model 1) or hyperlipidemia (β = −0.107, P = 0.038, Table 3, Model 2), but not with that for DM (β = −0.040, P = 0.442, Table 3, Model 3). The gene discussed is RNASEL; the disease is hyperlipidemia.