CD4 and malaria: In addition, evidence of suppression of T-cell cytokine responses was recently demonstrated in murine models of malaria [63], where a distinct sub-set of IL-27-secreting Foxp3−CD11a+CD49d+ malaria antigen-specific CD4+ T-cells inhibit the production of IL-2, which consequently may dampen IL-12 secretion, resulting in clonal depletion of Th1 cells [63].