Researches have demonstrated that CD4+ CD25+ Foxp3+ Tregs inhibited proliferation, activation, degranulation, and production of granzyme A, granzyme B, and perforin of CD8+ T cells induced by anti-CD3/CD28 antibodies [21] and are potent suppressors of autologous tumor-specific T cell responses [47]. This evidence concerns the gene CD8A and neoplasm.