As previously noted, while the association between the HLA-B*57:01 allele and ABC HSR has been extensively examined, limited data are available from other large randomized clinical studies that prospectively tested for the presence of the HLA-B*57:01 allele prior to randomization and reported on the frequency of the allele and its subsequent impact on the incidence of ABC HSR. The gene discussed is HLA-B; the disease is aneurysmal bone cyst.