SYK and acute myeloid leukemia: Therefore, we performed IHC analyses for phosphorylated SYK (pY348, a Syk-activating p-site) in the 21 AML cases overexpressing HOXA9 alone and in the 28 cases overexpressing both HOXA9 and MEIS1 (Figures 2C and 2D). This analysis revealed a significant association between strong SYK phosphorylation and HOXA9/MEIS1 overexpression (35.7% of H/M samples) compared with samples in which only HOXA9 was overexpressed (0% of H samples; p < 0.003, Fisher's exact test) or double-negative samples (13.6%; p = 0.024) (Figures 2C, 2D, and S2C).