FLT3 and acute myeloid leukemia: In addition, Syk has been shown to be activated by integrin signaling, to phosphorylate STAT5 in AML (Miller et al., 2013, Oellerich et al., 2013) and to cooperate with FLT3-ITD during the induction and maintenance of myeloid leukemias (Puissant et al., 2014).