Expression of THADA in the fat body using two fat body drivers, adh-GAL4 and mir278-GAL4 (see Figure S3B for expression patterns), partially rescued THADAKO obesity (Figures 1E and 1F), as did expression of THADA in all neurons (Figure 1H), indicating that defects in both the fat body and the nervous system contribute to the fat phenotype. Here, THADA is linked to obesity due to melanocortin 4 receptor deficiency.