Further, in hyperglycaemia, increased utilization of NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) by AR could result in decreased supply of NADPH co-factor to glutathione reductase that converts glutathione disulfide (GSSG) to glutathione (GSH) leading to decreased GSH reductase activity and in turn decreased GSH levels (Fig 1). The gene discussed is AR; the disease is Hyperglycemia.