As shown in Fi 3C, after receiving purified CD8- T lymphocytes, from immuno-competent tumor-primed Sure-L1 mice, HUMAMICE (No.139, 212 and 337) bearing a solid RAMOS tumor started to reject their tumors by reducing progressively their size from 6 days post-transfer, while the tumors continued to grow in control mouse No.323 that did not receive cell transfer. Here, CD8A is linked to neoplasm.