SYNE2 and Emery-Dreifuss muscular dystrophy: Mutations in nesprin-1 and -2 have been implicated in EDMD 4 (AD-EDMD 4, OMIM 612998) and 5 (AD-EDMD5, OMIM 612999), and SUN1 and SUN2 have also been implicated in EDMD (13–16).