The impact of the CACNA1C A allele on brain volume in BD type I has previously been evaluated in BD; two studies reported negative results,32, 57 whereas two reported increased volume associated with the A allele.1, 6 Perrier et al.1 reported that A carriers had increased GM density in the right amygdala and right hypothalamus in a sample of 41 BD euthymic type I patients compared to 50 HCs. The gene discussed is CACNA1C; the disease is Behcet disease.