DICER1 and conduction system disorder: Individuals who were homozygous for the ancestral A-allele had more conduct disorder behaviors than individuals with the G-allele.84 Another study found an association of a functional polymorphism in miR-124-1, which targets genes such as BDNF and DRDF, and aggressiveness, which could explain the effect of this miRNA on aggressive behavior.85 Recently, a gene-based association study showed potential involvement of DICER1 in suicide pathogenesis.86 DICER1 has a critical role in miRNA biosynthesis.