Vorinostat (also known as suberoylanilide hydroxamic acid; SAHA) is an orally bioavailable, non-specific HDACi, is the prototype of a series of hydroxamic-acid-based HDACi that has been shown to induce MM cell apoptosis, with increased p21 and p53 protein levels and dephosphorylation of Rb, sensitize MM cells to other agents and inhibit the secretion of IL-6 triggered by MM cell binding to BMSC, suggesting that SAHA can overcome cell-adhesion mediated drug-resistance [174]. This evidence concerns the gene IL6 and Miyoshi myopathy.