Further studies have shown that MM cells treated with SAHA exhibit myriad anti-proliferative and pro-apoptotic molecular events, including downregulation of transcripts for the IGF/IGF-1 receptor and IL-6 receptor signaling cascades, anti-apoptotic molecules (e.g., caspase inhibitors), oncogenic kinases, DNA synthesis/repair enzymes, and transcription factors (e.g., XBP-1, E2F-1) implicated in myeloma pathophysiology [3]. The gene discussed is IGF1; the disease is Miyoshi myopathy.