It is not completely clear if the RGD motif in the CagL proteins competes with the binding of the RGD motif containing fibronectin molecule to β1 integrin [126,127], but HtrA-mediated degradation of fibronectin might enhance the accessibility of β1 integrin for H. pylori to increase the translocation of the CagA oncoprotein and subsequently cancer-associated signal transduction. Here, FN1 is linked to cancer.