ADAM10 and gastric cancer: A recent publication shows that ADAM-10 and -17 mediated shedding of Notch1 contributes to the stem-like phenotype of gastric cancer stem cells and their inhibition reduces the capacity of anchorage independent proliferation [48] (Table 2, Figure 1) suggesting that H. pylori-activated proteases of the ADAM family could exert direct effects on neoplastic transformation.