Indeed, in a mouse ALS model, P2X7R inhibition led to a diminution of microgliosis associated with a decrease of M1 (IL-1β) and an increase of M2 (IL-10) markers, leading authors to consider P2X7R as a potential maker of M1 microglia in ALS [125]. The gene discussed is IL10; the disease is amyotrophic lateral sclerosis.