In addition, one previous study suggests that erythrocyte total n-3 fatty acids interact with genetic variant at PEPD gene (encoding peptidase D, which plays an important role in the recycling of proline and collagen metabolisms) to modulate T2D risk in a Chinese population, with higher n-3 fatty acids abolishing the adverse effect of the risk allele at PEPD on T2D [9]. Here, PEPD is linked to type 2 diabetes mellitus.