Acyl ghrelin chiefly has hyperglycemic effects [280] and promotes insulin resistance [281,282], acting on both pancreatic islets to suppress insulin secretion [283] and on hepatocytes to stimulate glucose output [284], whereas des-acyl ghrelin may counteract the hyperglycemic effects of acyl ghrelin and enhance insulin sensitivity [282,284,285,286]. The gene discussed is INS; the disease is Insulin resistance.