MYC and neoplasm: For instance, while most studies from the mammalian intestine highlight the capacity of Wnt to activate β-catenin/TCF4 binding to the MYC promoter in association with tissue overgrowth and tumour predisposition [82,83,84,85], Wnt signals drive terminal differentiation in Paneth cells in the intestinal crypt [86], inducing Myc in the crypt and CyclinD1 in the villi distinct cell populations [87].