Even though hsCRP did not significantly modify the association of either LPC(15:1) or PC(15:1/18:2) with insulin sensitivity in non-T2D cases (β = 0.24 [0.04–0.45], P = 0.02 and β = 0.27 [0.02–0.52], P = 0.035, respectively), the effect of LPC(17:0), PC(22:6/18:2) and LPC(20:1) on Matsuda ISI was blunted by the inclusion of hsCRP in the models (P > 0.05 for all). The gene discussed is INS; the disease is type 2 diabetes mellitus.