The second proband (MOC-F5), diagnosed with secondary glaucoma and iridocorneal endothelial syndrome, presented three rare non-coding GPATCH3 variants (c.-298_−295delGAGG, c.*263C > T and c.*274C > T) (Fig. 2A) with frequencies equal to or less than 1% (Table 1). The gene discussed is GPATCH3; the disease is iridocorneal endothelial syndrome.