However, knocking down LSD1 did not upregulate metastasis-associated miRNAs in either LnCAP cells or in RWPE-1 cells overexpressing AR, HOXC6 or NKX2-2 (Supplementary Fig. 8A–D), suggesting that other co-factors mediate the transcriptional repression of miRNAs in prostate cancer. Here, NKX2-2 is linked to Familial prostate cancer.