To infer the driver TF-associated miRNA regulatory network, we employed a minimum description length (MDL) procedure (Fig. 1c), which seeks to explain the observed aberrant expression pattern of miRNAs (observed in all metastatic cancers) by a minimum number of aberrantly expressed TFs (each occurring in a subset of metastatic cancers). The gene discussed is TF; the disease is metastatic malignant neoplasm.