Furthermore, another reported work identified salivary and serum levels of IL-8, IL-6 and TNF-α in patients of oral leukoplakia, oral lichen planus, oral submucous fibrosis, and their results showed high concentrations of all cytokines, which again proved to be diagnostic markers for oral precancerous lesions [35]. The gene discussed is CXCL8; the disease is oral lichen planus.