It is remarkable how MPC1 and MPC2, PDHA1 and PC—genes that are involved in the transport and conversion of pyruvate in the inner mitochondrial matrix, respectively—are all significantly downregulated in a subset of colon adenocarcinomas categorized as colon mucinous adenocarcinomas, as loss of these genes essentially shuts down oxidative phosphorylation in the mitochondria (Figure 6—figure supplement 1). The gene discussed is MPC2; the disease is digestive system cancer.