Lentiviral-vector directed PCR primers were then used to identify a human cDNA in the selected cells, that encoded human monocarboxylate transporter 1 (hMCT1, also known as SLC16A1, Figure 2—figure supplement 1B), a 12-pass transmembrane protein that mediates the transport of monocarboxylates such as lactate and pyruvate across the plasma membrane, and is upregulated in some cancers (Halestrap, 2012, 2013). The gene discussed is SLC16A1; the disease is cancer.