UGT1A1 and neutropenia: The association in Fig. 8 satisfied either of the 3 conditions described below: (I) the association was statistically significant as shown in the target study; (II) the association between the polymorphism of UGT1A1 *28 or SLCO1B1 c.521T>C and side effects (neutropenia, diarrhea) was statistically significant in other reported studies, though not in the target study; and (III) the side effect diarrhea shows an association with biliary index (37).