Similarly, when the correlation of Rdif,h(SN-38) and the reproduction frequency of the impact of SLCO1B1 c.521T>C polymorphism on increasing the neutropenia was plotted using 30 sets of parameters (Supplementary Fig. 4B), the set of parameters having a large Rdif,h(SN-38) could not reproduce the effect of SLCO1B1 c.521T>C on neutropenia with high frequency. Here, SLCO1B1 is linked to Decreased total neutrophil count.