Several differences with respect to clinical characteristics and outcomes between HCC in C&A and that in adults have been reported.4,20 Our results identified HBV infection to be present in 81.5% of C&A with HCC, which is similar to the prevalence of adult HCC in our hospital.21,22 In accordance with other studies, we found that HCC was more common in males than in females (4:1).3,5 AFP is a useful diagnostic marker for HCC, and roughly 50–70% of adults with HCC have increased levels of AFP,3,23 compared with >90% in C&A in our study. Here, AFP is linked to hepatocellular carcinoma.