Notably, increased adipose tissue levels of multiple β-chemokines (CCL2, CCL3, CCL5, CCL7, CCL8, CCL11) and chemokine receptors (CCR1, CCR2, CCR3, CCR5) have been linked with obesity and associated metabolic inflammation [31]. Here, CCL8 is linked to obesity due to melanocortin 4 receptor deficiency.