The T-helper (Th)-17 cells express proinflammatory cytokine IL-17 which regulates adipogenesis, glucose homeostasis and obesity [14]; and it has been also implicated in the pathogenesis of several inflammatory diseases including rheumatoid arthritis, psoriasis, systemic sclerosis, and T2D [15–18]. The gene discussed is IL17A; the disease is type 2 diabetes mellitus.