Of the ccRCC tissues, 67% of the cases (score 1: 18 cases; score 2: 32 cases; score 3: 17 cases) showed positive staining of SMURF1, while SMURF1 signal was detected in only 35% (score 1: 15 cases; score 2: 16 cases; score 3: 4 cases) of samples of tumor‐adjacent specimens (P < 0.05, Fig. 1). This evidence concerns the gene SMURF1 and nonpapillary renal cell carcinoma.