Regulatory networks constructed for the overlapping genes demonstrated that miR‐132 in HCC might interact with RAC1, PTGS2, and NRAS via VEGF signaling pathway, mediate biological processes with SMAD4, YES1, and IQGAP1 via adherens junction, associate with TRAF6 and IRAK1 via TLR signaling pathway, and interplay with SORT1 via neurotrophin signaling pathway. The gene discussed is PTGS2; the disease is hepatocellular carcinoma.