Zhou et al. 34 stated that miR‐100 suppresses HCC metastasis by abolishing the ICMT‐Rac1 signaling and negatively correlates with metastasis in HCC, whereas Wu et al. argued that miR‐142‐3p negatively regulates RAC1 and is able to suppress the migration and invasion of HCC cells 35, both of which happened to cover the involvements of certain individual microRNAs in HCC and merit attention for the further verification of RAC1 and miR‐146a‐5p in HCC. The gene discussed is RAC1; the disease is hepatocellular carcinoma.