In conclusion, cinnamon polyphenol has been reported to have several beneficial effects on obesity through the modulation of transcription factors including SREBP-1c, LXRs, NF-κB, and Nrf2 and several enzymes such as ACLY and FAS and insulin resistance, glucose, and lipid metabolism and antioxidant status. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.