Most studies described above suggest that hypermethylation and silencing of miRNAs plays a pro-tumorigenic role in melanoma and that ectopic expression of specific miRNAs could attenuate melanoma proliferation and metastatic potential by targeting EMT signaling, PI3K/AKT pathway, or p53 signaling in vitro and in animal models. This evidence concerns the gene AKT1 and melanoma.