Seven genes were reported as hypermethylated in melanoma (COL1A2, FRZB, GSTM2, KCNK4, NPR2, TRIP6) and 19 genes were reported as hypomethylated, (CD2, EMR3, CARD15, EV12A, HLA-DP1, IFNG, IL2, ITK, KLK10, LAT, MPO, PSCA, PTHLH, PTHR1, RUNX3, and TNFSF8). This evidence concerns the gene COL1A2 and melanoma.