TP53 and cancer: This methionine metabolism “reprogramming” results in global [5, 6] and gene-specific [64] DNA hypomethylation, another general defect in cancer, which in turn leads to aneuploidy, another general defect in cancer which in turn leads to cancer “speciation.” Vogelstein et al. [65] reported that inactivation of p53 did not lead to aneuploidy.