The SNP rs17782313 was significantly associated with low adiponectin under a recessive model after adjustment for age, gender, and BMI or obesity statuses (OR = 0.700, 95% confidence interval (CI): 0.490–1.000, P = 0.050; OR = 0.699, 95% CI: 0.491–0.996, P = 0.048, resp). Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.