MICA and chronic graft versus host disease: Patients’ genotype at position 129 was firstly analyzed in a cohort of 211 matched related allogeneic HCT patients, and it was shown that those bearing the MICA-129 Val/Val genotype—i.e., the lower binding affinity variant—were at a higher risk of developing chronic GVHD (63 vs. 45% at 3 years; P = 0.03) (12).