MICA and cancer: In other fields of research such as cancer and infectious diseases, several MICA polymorphisms have been reported to affect MICA shedding including an SNP (rs2596542) in the promoter region (86–89), the microsatellite MICA A5.1 (35, 90, 91), and the MICA-129 Met/Val dimorphism in α2 domain of the MICA protein (88, 92, 93).