In an in vitro study, we found that peripheral basophils that were negatively isolated from healthy controls (Figure 2E) could be activated by the upregulation of CD203c expression (Figure 2F—a) and that the percentage of IL-4-positive cells (Figure 2F—b) could be increased by culturing with serum obtained from newly diagnosed patients with SLE, and IgE-CICs (Figure 2D) precipitated by PEG from the sera of newly diagnosed patients with SLE, but not by the serum of healthy controls or serum obtained from newly diagnosed patients with SLE by depletion of IgE. This evidence concerns the gene IGHE and systemic lupus erythematosus.