In addition, antinuclear IgE specific for auto-antigens, including nRNP/sm, Sm, SS-A, Ro-52, dsDNA, nucleosomes, rib-Prot, etc., can be detected in patients with SLE (n = 36) but not in healthy controls (n = 36) (Figure 2C). This evidence concerns the gene TRIM21 and systemic lupus erythematosus.