ENPP3 and systemic lupus erythematosus: Furthermore, a follow-up study showed that after treatment with immunosuppressants and other drugs, newly diagnosed patients with SLE who experienced effective treatment (defined as a decrease in the SLEDAI score of more than 6 and the absence of damage to the heart, lungs, brain, blood, intestines, or any other vital organs) showed an increased level of peripheral basophils and decreased basophil activity as indicated by the expression of CD203c (Figure 1D, nos.1–13); in contrast, patients who did not experience effective treatment did not show any of these signs (Figure 1D, nos.14 and 15).