The results showed that serum levels of anti-dsDNA IgE, antinuclear IgE and total IgE (Figure 2A), IgE-CIC (Figure 2D) in newly diagnosed patients with SLE were significantly higher than those in healthy controls, which was reconfirmed by the higher expression of the high-affinity receptor for IgE (FcεRIα) on basophils (Figure 2B). The gene discussed is IGHE; the disease is systemic lupus erythematosus.