CCR7 and systemic lupus erythematosus: Additionally, basophils were first detected in the lymph nodes of 10-week-old MRL-lpr/lpr mice and increased slightly in number as the mice aged (Figure 4D), a finding that is consistent with the upregulated expression of the homing receptors CD62L and CCR7 on basophils obtained from patients with SLE (Figure 3A).